ODT and DOCX are both zipped XML, built by rival standards bodies. Plain text and headings move over perfectly; some layout features have no exact counterpart. Choose what's in your document to see a feature-by-feature report before converting.
We converted one source document into every major output format and measured the file that came out. The source was a 37.4 KB DOCX with headings, bold and italic text, a table, numbered and bulleted lists, and one embedded image.
Sizes are from one representative document converted with Pandoc and LibreOffice. Your own files will differ, especially with more images, but the relative ordering holds.
A PDF has no paragraphs. It stores “draw these glyphs at x, y in this font”, often one word or one line at a time, and a scanned page stores only a picture. Drop any PDF to see which kind you have and what its page instructions look like.
LibreOffice ships free fonts drawn to match Microsoft's letter widths, so text breaks at the same place. Fonts without a twin reflow, and page 40's heading lands on page 41. Pick the font your document uses.
Sending a draft to a supervisor or client? Tracked changes and comments carry over as real Word revisions, with names and dates. Toggle what goes into the DOCX.
Microsoft Word, Google Docs and Pages all read ODT. Converting is worth it when a portal, template or reviewer asks specifically for .docx, or when you'll keep editing in Word.
Neighbouring tools, with a typical result for each.